Session Index

Biophotonics and Biomedical Imaging

Biophotonics and Biomedical Imaging V
Saturday, Dec. 4, 2021  09:00-10:30
Presider: Biomedical Sensing: Prof. Chii-Wann Lin & Prof. Nan-Fu Chiu
Room: 303b
09:00 - 09:30
Manuscript ID.  0729
Paper No.  2021-SAT-S0605-I001
Invited Speaker:
Ji-Xin Cheng
Bond-Selective Imaging by Optically Sensing the Mid-Infrared Photothermal Effect
Ji-Xin Cheng

09:30 - 09:45
Manuscript ID.  0162
Paper No.  2021-SAT-S0605-O001
Yu-Sheng Lu The cylindrical solid-state sensor used for the detection of zinc ion in clinical applications
Yu-Sheng Lu;Li-Yin Chen

Zinc ion is the second largest transition metal ion in human body, and the concentration of zinc ion around axons is around 10-6 M. The concentration of zinc ion is a useful indicators for physiological states especially in brain and nerves. Therefore, it is helpful for clinicians’ medical treatment if the concentration of zinc ion in the injured brain and central nervous system can be detected in real time. Thus, we design a minimized fiber-based sensor coated with a hydrogel containing sensing molecules. The fiber-based sensor can be a candidate to detect the concentration of zinc ion in real-time applications.

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09:45 - 10:00
Manuscript ID.  0115
Paper No.  2021-SAT-S0605-O002
Syu-Cing Ma Analysis of the biochemical reaction status by real-time monitoring the molecular diffusion behaviors in a TFT sensor integrated with a microfluidic channel
Syu-Cing Ma;Ya-Chu Lee;Jin-Chun Lim;Yao-Hsuan Lai;Jian-Jang Huang

In this work, the metal-oxide TFT (thin-film transistor) biosensor integrated with a microfluidic channel was developed to investigate biochemical reaction kinetics. Using the malate-aspartate shuttle as an example, we established the correlation between the molecular diffusion behaviors in the microfluidic channel and the TFT current responses. Mixtures of different reagent concentrations were characterized to extract the ratio between NAD+ and NADH, and thus determining the apparent equilibrium constant. Because the whole analysis was conducted by a TFT sensor fabricated using semiconductor process, it has the advantages of exploring biochemical reaction kinetics in the massively parallel manner.

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10:00 - 10:15
Manuscript ID.  0202
Paper No.  2021-SAT-S0605-O003
Keng-Yi Tsai In-situ Stability Feedback Control of an Electrochemical Sensor Integrated with a Thin-Film Transistor for L-dopa Detection
Keng-Yi Tsai;Ya-Chu Lee;Jian-Jang Huang

In this work, we propose a new biosensing setup that includes a typical electrochemical(EC) biosensor, a TFT (thin-film transistor) and a constant current source. The integrated circuit provides a negative feedback control to mitigate current fluctuations induced during the voltammetry detection of the EC biosensor. Using levodopa (L-dopa) molecules as the target analyte, our new structure demonstrated a LOD an order of magnitude lower than the traditional EC sensor because of a lower standard deviation among the tested samples

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10:15 - 10:30
Manuscript ID.  0581
Paper No.  2021-SAT-S0605-O004
Chia-Ming Yang 2D bio images of PC-3 cells on NbOx LAPS
Tzu-Min Huang;Chun-Hui Chen;Chia-Ming Yang

By culturing different amounts of PC-3 cells on NbOx/n-si Light-addressable potentiometric sensor (LAPS), the cell metabolism responses can be and quantitatively studied on the basis of a biocompatible LAPS chip with self-developed LAPS LAPS measurement system. The real-time 2D chemical images and PC-V curves can be easily generated automatically for surface charge relative potential monitoring.